Current Projects
Nutrition, Sarcopenia, Physical Function, and Skeletal Muscle Capacity During Aging
Project funded by USDA/ARS
PI: Roger A. Fielding
This grant supports the core functions of the Nutrition, Exercise Physiology and Sarcopenia Laboratory and its mission is to conduct research into how exercise and diet can influence age-related loss of skeletal muscle mass and function (sarcopenia). Projects include both human and animal studies, ranging from the molecular level to population-based observational and intervention studies.
Boston Older Americans Independence Center: A Translational Approach to Function Promoting Anabolic Therapies
Project funded by NIH/NIA
PI: Shalender Bhasin
Co-I: Roger A. Fielding
The major goals of the Boston OAIC are to expedite the translation of research results into evidence-based function promoting anabolic therapies and to nurture a new generation of aging researchers.
Characterising Sarcopenia and Sarcopenic Obesity in patients Aged 65 years and over, at risk of mobility disability: An Observational Clinical Trial
Project funded by Biophytis S.A./ICON
PI: Roger A. Fielding
The major goal of this single arm phase 2 clinical trial is to study 300 community dwelling older adults reporting loss of physical function and are at risk of mobility disability. Participants will undergo mobility functional evaluation and dual-energy x-ray absorptiometry (DXA) scan for body composition.
Impact of exercise on kidney function and Injury among elders in the LIFE trial
Project Project funded by NIH/NIA
PI: Michael Shlipak, Steven G. Coca
Co-I: Roger A. Fielding
The goal of this project is to measure the impact of structured physical activity (SPA) intervention compared with a health education (HE) intervention on reducing kidney function decline.
Senescence and Growth and Differentiation Factors as Modifiers of Aging
Project Project funded by NIH/NIA
PI: Nathan LeBrasseur
Co-I: Roger A. FieldingThe goal of this project is to develop data on measures of senescence-related factors in human samples from previously conducted randomized trials in older adults.
Impact of aging and influenza respiratory tract infection on muscle health
Project Project funded by NIH/NIA
PI: Haynes
Co-I: Roger A. FieldingThe goal of this project is to identify mediators involved with age-related flu-induced myopathies that will help us to formulate mechanistic hypotheses about how this happens and how it can be prevented in order to keep elderly people healthier longer.
Therapeutic Role of L-Carnitine and Creatine in Skeletal Muscle Hypertrophy
Project Project funded by Lonza
PI: Roger A. FieldingThe major goal of this project is to evaluate the effect of Carnitine and Creatine intake on skeletal muscle protein synthesis.
Effect of a ghrelin receptor agonist on muscle and bone
Project Project funded by NIH/NIAMS
PI: Bess Dawson-Hughes
Co-I: Roger A. Fielding
The major goal of this project is to determine the effect of a ghrelin receptor agonist on bone remodeling, lean tissue mass, and muscle function in adults with low bone and muscle mass.
Optimizing dietary carbohydrates to diminish inflammation and age-related eye disease
Project Project funded by USDA/AFRI/NIFA
PI: Allen Taylor
Co-I: RowanThis proposal seeks to elucidate relationships between carbohydrate intake, gut microbiota, inflammation, and age-related macular degeneration.
Exploiting Nutrition and Protein Quality Controls to Delay Age-related Macular Degeneration and Cataracts
Project Project funded by USDA/ARS
PI: Allen Taylor
The major goal of this project is to determine the extent to which – and mechanisms by which – the ubiquitin proteolytic pathway is involved in removal of damaged lens proteins and in maintaining lens clarity.
Ubiquitin function in eye lens
Project Project funded by NIH/NEI
PI: Allen Taylor
In this revised, funded grant, we will determine how Cdk1 and p27 cooperate to direct lens fiber cell denucleation.